Fertility is of central interest in the dairy production but has during the last decades declined. Increased milk yield has resulted in high pressure on the metabolism of the dairy cows that are supposed to manage the transition from dry cows to lactating cows within a few weeks around the parturition. Much indicate that metabolism and fertility are closely linked, with insulin playing a substantial part. There are many studies suggesting that the main part of gestation loss can be found during the early embryo development, a period which can be studied in vitro. The aim of this study was to test the effect of insulin during maturation in vitro and to evaluate two different fluorescent stainings on oocytes and embryos; a nuclear stain and a staining of apoptotic cells through the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-method. Bovine cumulus-oocyte-complexes (n=991) were aspirated from abattoir-derived ovaries.

Tidigt i läkemedelsutvecklingen är det centralt att välja ut substanser som har potential att bli väl fungerande läkemedel. En faktor som tas stor hänsyn till är substansens in vitro potens. Det finns få studier kring hur in vitro potensen förhåller sig till terapeutisk plasmakoncentration av det färdiga läkemedlet hos patienten, men ett vanligt antagande är att den terapeutiska plasmakoncentrationen är en till tre gånger högre än in vitro potensen. I min litteraturstudie har jag fokuserat på följande frågeställningar: - Hur förhåller sig in vitro potens till terapeutisk plasmakoncentration? - Är det sätt som läkemedelsindustrin tolkar in vitro potens till terapeutisk plasmakoncentration optimalt? In vitro potens-data och terapeutisk plasmakoncentration samlades in för nio etablerade läkemedelssubstanser.

The purpose of this study is to analyze the economic effects of different fertilization programs both on stand- and forest-level. The study is applied on an objective sample of inventory data for a forest area in Kalix in northern Sweden. The forest area belongs to the forest company Sveaskog. The study includes different economic models and will be used as a support when the company decides how to invest and how much to invest in fertilization. The study investigates the economy of five different fertilization policies. For each program the rate of interest invested in fertilization and the cost for the extra produced volume has been calculated.

This thesis analyzes the effects of different fertilization strategies on forest management at Holmen Skog in Umeå district. Harvesting volumes, net present values and fertilization intensity are presented for each fertilization scenario. The planning reserve (percentage area older than minimum final felling age) was also analyzed in this study.The thesis covers the analysis of five different fertilization scenarios, varying in fertilization intensity, from no fertilization at all, to fertilization at every harvesting operation (thinning or final felling). A sub-study was also carried out so the reader in detail can see how the different fertilization scenarios affect individual forest stands of different nature. The analysis has been done with the planning tool PlanWise, which is an application of the Heureka analysis and planning system.

This thesis analyzes the effects of different fertilization strategies on forest management at Holmen Skog in Umeå district. Harvesting volumes, net present values and fertilization intensity are presented for each fertilization scenario. The planning reserve (percentage area older than minimum final felling age) was also analyzed in this study.The thesis covers the analysis of five different fertilization scenarios, varying in fertilization intensity, from no fertilization at all, to fertilization at every harvesting operation (thinning or final felling). A sub-study was also carried out so the reader in detail can see how the different fertilization scenarios affect individual forest stands of different nature. The analysis has been done with the planning tool PlanWise, which is an application of the Heureka analysis and planning system.

The background for this thesis is that at the beginnings of 1980´s the National Board of Forest started an experiment of lime dressing to reduce acidification in forest soil and in ground water. The purposes of this report are to explain organization?s, government?s and private landowners viewpoint on lime dressing and vitalization fertilization, some socio-economic aspects are presented. The general conclusions are that the majority of the interested party?s are positive to vitalization fertilization but the forests owner?s in generally need much more information about this topic..

Ovarian stimulation in assisted reproduction often leads to the production of a high number of oocytes. After fertilization of these oocytes, the resulting embryos can be cryopreserved for later use. Vitrification is a recently introduced method for cryostoring embryos, showing high survival rates for both cleavage stage embryos and blastocysts. Characteristic of vitrification are high concentrations of cryoprotectants and ultra fast freezing which makes the material glassily. A major concern with vitrification has been the direct contact of the cryo-solutions with liquid nitrogen.

?Are the headwaters streams at the right position in the map? is a study that has been performed on behalf of Holmen Forest, region Örnsköldsvik. This study will be the basis for deciding if the Hydrology Layer Property map or Holmen Forest map will be used for planning nitrogen fertilization in forestry. The background to this study is that nitrogen fertilization near water will increase the risk of nitrogen leaching out into the water systems, which has a negative impact on the environment. The headstreams positions have been recorded in the field with a GPS and the data analyzed in the geographic information system ArcMap.

Antalet läkemedel som lanseras på marknaden har minskat under mer än ett decennium, vilket väcker frågan om huruvida det finns brister i de metoder och resonemang som används vid utvecklingen av ett nytt läkemedel. Syftet i den här litteraturstudien var att utreda delar av frågan kring eventuella brister med hjälp av följande frågeställningar: Vilka in vitro potenser kan man hitta vid en litteratursökning för några på marknaden etablerade humana och/eller veterinära läkemedelssubstanser? Hur förhåller sig in vitro potensen för dessa substanser till den terapeutiska plasmakoncentrationen/det terapeutiska intervallet som har fastställts för dem? Vad finns det i dagsläget för teorier kring eventuella brister i den rådande läkemedelsutvecklingsprocessen? In vitro potens-data för nio etablerade läkemedelssubstanser samlades in och jämfördes med respektive substans terapeutiska plasmakoncentration och en kvot erhölls som sedan relaterades till det resultat som presenterades i en mastersuppsats i farmaci av Fabian Göransson där motsvarande kvot genererades för 150 etablerade läkemedelssubstanser. Det sammanvägda resultatet, med tyngdpunkt på Fabians Göranssons resultat, visar att antagandet att den terapeutiska plasmakoncentrationen är minst tre gånger högre än in vitro potensen kan leda till främst överestimering men också underestimering av den terapeutiska plasmakoncentrationen och att substanser tenderar att vara mer potenta in vivo än in vitro. Därför behövs en högre grad av flexibilitet när ovan nämnda antagande praktiseras under läkemedelsutvecklingsprocessen. Efter en kortare utblick över några teorier kring brister i dagens läkemedelsutvecklingsprocess verkar det som att läkemedelsindustrin behöver revidera samt ifrågasätta lämpligheten hos de principer som idag praktiseras inom området. .

Infertilitet är en utbredd problematik som drabbar många par världen över. Olika behandlingsformer finns att tillgå för att hjälpa infertila par att uppnå en graviditet. IVF-behandling är en vanlig behandlingsform. Många studier visar att IVF-behandling påverkar kvinnan mer än mannen psykiskt. Syftet med denna studie var att beskriva hur kvinnor upplever processen att genomgå IVF-behandling.

An increasing demand for wood products in China has resulted in large areas invested in fast-growing tree plantations of eucalyptus. Eucalyptus plantations are often associated with an intensive management including fertilization. By understanding the effects of fertilization and where in the ecosystem nutrients are accumulated a more sustainable forest management could be achieved. In this study, a nutrient budget including all biomass and soil components was created for Eucalyptus urophylla. The examined nutrients were nitrogen, phosphorus and potassium.

Av par i fertil ålder som aktivt försöker få barn är det 10-15 procent som inte lyckas inom ett år och räknas då till kategorin ofrivilligt barnlösa. Att drabbas av ofrivillig barnlöshet innebär stor sorg och prövning för det drabbade paret. Med hjälp av assisterad befruktning kan parets möjligheter till graviditet öka. En IVF-process innebär psykisk och fysisk påfrestning, vilket ställer stora krav på vårdens bemötande, kompetens och stöd. Denna studie syftar till att undersöka hur par som genomgår IVF-behandling upplever vårdens bemötande samt om och i så fall hur parets relation påverkats under och efter IVF-processen.

Peat  lands  are  a  great  potential  resource  for  increased  forest  growth  in  Sweden, there  are  approximately  6.5  million  hectares  of  peat  lands,  whereof  around  70% produce less wood than one m3sk/ha and year and are therefore classed as forest waste  land.  There  are  over  200  000  hectares  of  peat  land  that  is  already  drained and  wooded,  and  that may  be  suitable  for  fertilization.  Forest  production  on  peat soils  usually  requires  drainage  and  fertilization.  Dewatering  requires  ditching  the area, so that the roots can have access to oxygen. Nitrogen is often abundant in the peat but other nutrients; especially potassium is in short supply. The  purpose  of  this  work  was  to examine  the effects  of  potassium  fertilization  on the  growth  of  spruces  that  were  planted  on  drained  peat  land  and  how  different amount of fertilizers affects the growth. Potassium deficiency is strongly growth inhibiting, since potassium is important for substance  transport  in  the  tree.  Potassium  is  also  important  for  the  carbohydrate formation, and because increasing the sugar content of the cells constitutes a lower freezing temperature does potassium availability in the soil play a major role in the winter  resistance  of  many  species.  Potassium  is  not  found  in  any  organic compounds in the tree, but is present in cell and tissue fluids. A fertilization trial was started in 1978 in Siljansfors Experimental Forest. The plots in the experiment were fertilized with different amounts of potassium and one plot was  left  without  fertilization.  All  plots  that  were  fertilized  with  potassium  grew considerably better than the unfertilized plot. The difference in production between the unfertilized plot and the plot that received the most potassium was 7.2 m3sk/ha and year. The unfertilized plot can still be classified as waste land. The theoretical production capacity was estimated using a Swedish system for site quality  estimation  of  wetlands  after  ditching  (dikningsbonitering).  The  plot  with most  potassium  produced  after  fertilizationaproximately  in  level  with  theoretical estimations.  Key  words:  Peat  land,  Fertilization,  Ditching,  Growth,  site  quality..

Syfte Syftet med den h?r systematiska litteratur?versikten var att unders?ka evidensen f?r om en viktnedg?ngsbehandling genom energireducerad kost, med eller utan till?gg av fysisk aktivitet, inf?r in vitro-fertilisering (IVF) hos kvinnor med obesitas har en p?verkan p? f?delsetal och graviditetstal. Metod Litteraturs?kningen genomf?rdes i databaserna Pubmed och Scopus den 23 januari 2023. Artikelselektionen utf?rdes systematiskt med hj?lp av en avgr?nsad fr?gest?llning samt inklusions- och exklusionskriterier. Populationen utgjordes av kvinnor med obesitas som planerade att genomg? IVF.

Variation in tuber quality within a single field was one of the motives for a pilot study in Halland, in south-western Sweden conducted during 2002. Quality problems in potatoes have been increasing due to the aggregation of several small fields with different land use history into larger farm units, which are heterogeneous in soil properties and fertility. The study in Halland indicated that both the uniformity and the mean size of tubers may increase from site-specific K fertilization, whereas total yields may be unaffected. The results from this pilot-study with site-specific fertilization showed that tubers reached a more uniform quality and gave a more uniform mean size, while the total yield wasn't affected at all. Site-specific K-fertilization has been applied for some years in Halland with good results. The aim of this study was to test this technique in another potato growing area.